Fibrates are often used when triglycerides are very high because of hepatotoxic considerations. Which option best reflects this usage?

• A. They are contraindicated in triglycerides above 1000 mg/dL
• B. They are primarily used to lower LDL cholesterol
• C. They have no risk of hepatotoxicity
• D. They are used when triglycerides exceed 1000 mg/dL because hepatotoxic risk is a concern

Answer: (D)